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45 results about "Mammotroph" patented technology
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Mammotroph An obsolete term for a cell that produces prolactin; prolactin-secreting cell is the preferred term in the working medical parlance.
Method for targetedly integrating exogenous gene into target gene
InactiveCN104342457AOvercoming Random Integration ProblemsLess expensiveMicroinjection basedVector-based foreign material introductionMammalPosition effect
The invention discloses a method for targetedly integrating an exogenous gene into a target gene of a mammal, which is implemented by targetedly integrating an exogenous gene into a target gene by utilizing a CRISPR / Cas9 system, and especially targetedly integrating a Cre gene to a first exon of a mouse Enpp1 gene. The technique has the advantages of high integration efficiency (20%) and simple operation step, only needs to construct one exogenous gene vector, and can not be influenced by the position effect.
Owner:HANGZHOU NORMAL UNIVERSITY
Skin photoaging prophylactic agent
InactiveCN101301297APrevent photoagingPrevent agingCosmetic preparationsOrganic active ingredientsAdditive ingredientMammal
The objective of the invention is to provide a photo-aging prophylactic agent for skin with novel ingredients and foods using the photo-aging prophylactic agent for skin, medicaments for mammals including human beings and a skin external agent, as well as feed for mammals. The inventive photo-aging prophylactic agent for skin is characterized by taking extracts of Orobanchaceae plants as effective ingredients. The photo-aging prophylactic agent for skin preferably comprises phenylethanoid glycosides compounds as effective ingredients. Moreover, the photo-aging prophylactic agent for skin preferably comprises at least one of echinacoside and acteoside as the phenylethanoid glycosides compounds. On top of that, the photo-aging prophylactic agent for skin preferably comprises both echinacoside and acteoside as the phenylethanoid glycosides compounds. In addition, the photo-aging prophylactic agent for skin can be employed as medicaments for mammals including human beings, skin external agents, consumptive foods and feed for mammals.
Owner:SINPHAR TIAN LI PHARMA
Anti-coagulation nano silver antibiotic dressing
InactiveCN1473553AHas broad-spectrum antibacterial propertiesThe content is easy to controlFibre treatmentAdhesive dressingsFiberSurface layer
The present invention relates to antibiotic dressing for treating injury of mammal, especially human body, and is especially a kind anti-coagulation nano silver antibiotic dressing prepared via anti-coagulation technology. The antibiotic dressing includes a kind of fabric and composite nano silver particles deposited onto the fabric, and the composite nano silver particles in the size of 1-100 nm are attached firmly between the fiber elements and on the fiber. The composite particles have core of metal silver and surface layer of silver oxide, which accounts for 10-80 wt% of the whole composite particles, and the silver content of the dressing is less than 50 microgram each squared millimeter.
Owner:SHENZHEN TSINGHUA YUANXING NANO MATERIAL CO LTD
Electroporation method for transfection of mammal embryo with siRNA (small interfering Ribose Nucleic Acid)
InactiveCN102329819AIncreased mortalityStrong penetrating powerFermentationGenetic engineeringCell membraneRoom temperature
The invention discloses an electroporation method for transfection of mammal embryo with siRNA (small interfering Ribose Nucleic Acid). The electroporation method comprises the following steps: (1) weakening an embryo zona pellucid; (2) preparing electroporation solution containing siRNA; and (3) conveying the embryo into the prepared electroporation solution containing siRNA, standing at the room temperature, and then conveying the embryo and the electroporation solution into an electric turn trough for electroporation. The electroporation method comprises the steps of weakening the embryo zona pellucid and complexing the siRNA, and then placing the embryo under the action of a pulsed electric field to increase the permeability and the membrane conductance of the embryo instantaneously, and thus the siRNA which is difficult to penetrate through a cell membrane under the normal physiological condition enters the cell. Statistic observation and analysis prove that the stable positive transfection efficiency of survival embryos exceeds 95%, and the practical effective utilization rate of the collected total embryo exceeds 70%. The electroporation method is a safe, simple and efficient transfection technology of mammal embryo with siRNA.
Owner:NORTHWEST A & F UNIV +1
Lyrica preparation method
ActiveCN101585778AStarting materials are readily availableFew reaction stepsNervous disorderOrganic compound preparationDecompositionPregabalin
The invention discloses a lyrica preparation method. Lyrica is an analogue of a mammal neurotransmitter of Lambda-propalanine, is clinically used for curing diabetic peripheral neuralgia and post-herpetic neuralgia and adjunctively treating partial adult seizure. The Lyrica is synthesized through using S-(+)-leucine as a raw material by a chemical method without decomposition, and has the advantages of easily obtained raw materials, less reaction steps, mild reaction conditions, high reaction yield, and the like.
Owner:SHANGHAI CHENPON PHARMA TECH
Method for increasing litter size of multiparous animals
ActiveCN104938418AIncrease litter sizeImprove reproductive performanceAnimal feeding stuffOral medicationMammal
The invention provides a method for increasing the litter size of multiparous animals through oral administration of melatonin. The method increases the litter size of the multiparous animals by adding melatonin in fodder or drinking water of the multiparous animals in the gestation period so as to achieve the purpose of improving the fecundity of the animals. The method can increase the average litter size of mammals like mice by 0.48-1.38, and provides a good reference for research on improving the fecundity of mammals.
Owner:内蒙古金草原生态科技集团有限公司
Composition and kit for quickly extracting circulating un-related karyocyte from peripheral blood of animal disease model, as well as application thereof
InactiveCN102952781AHigh recovery rateShorten centrifugation timeSamplingBlood/immune system cellsSurface markerRed blood cell
The invention relates to a composition and kit for quickly extracting circulating un-related karyocyte from peripheral blood of an animal disease model, as well as application thereof. The composition which is used for quickly acquiring circulating un-related karyocyte from mammal blood of an animal disease model (including a tumor animal model, a cardiovascular disease animal model and the like consists of buffer fluid, magnetic or non-magnetic immunomicrospheres coated by anti-related karyocyte surface marker antibody, and cell separation medium with certain density. Compared with commercial centrifugal medium which is universally applied currently on the market, the centrifuge time can be greatly shortened by applying the novel composition, and the cell recovery rate is stably increased to over 95 percent from the previous 60+ / -20 percent. The erythrocyte is not required to be cracked, molten and broken by means of the method, so that the un-related circulating rare cells can be enriched and extracted from the peripheral blood in the animal disease model effectively and quickly.
Owner:卢焕梅
Hematopoietic stem cell culturing apparatus and method
The present invention relates to apparatus and method of culturing mammal cell, and is especially culturing apparatus and method for selective amplification of human stem cell, including hemopoietic stem cell. The apparatus and method of the present invention may be used widely in biological treatment of tumor and transplantation of hemopoietic stem cell.
Owner:高春平
Bone-melon extract injection and preparation thereof
InactiveCN101297853AHigh content of active ingredientsHigh yieldSkeletal disorderUnknown materialsDiseaseOsteoblast
The invention provides a drug of bone-melon extract for injection, mammalian bone peptides and melon seed peptides are extracted, the obtained extracts are mixed according a certain proportion, thus preparing the drug for injection. The invention adopts a special extraction technology to increase the active ingredients, the extraction efficiency is high, and the substances with high molecular weight are reduced to the minimum. The drug of the invention has the effects of regulating bone metabolism, stimulating proliferation of osteoblasts, promoting formation of new bones, regulating calcium and phosphorus metabolism, increasing bone calcium deposition and preventing osteoporosis, thus being used for prevention and treatment for rheumatism, rheumatoid arthritis, osteoarthritis, lumbar and leg pain, fracture trauma repair and other diseases.
Owner:杨拴定
Paramagnetic metal manganese doped multi-complex as magnetic resonance imaging contrast agent
InactiveCN1879896AImprove solubilityHigh relaxation efficiencyNMR/MRI constrast preparationsHeteropoly acidUltrasonic imaging
The invention relates to a magnetic resonance imaging contrast agent, which uses paramagnetism manganese heteropoly complex, wherein the inventive contrast agent is the high-stability chelate formed by transition paramagnetism manganese and heteropoly acid or heteropoly acid salt with Keggin or Dawson structure, which has target property and better signal strengthen effect on the liver, kidney, etc. And the inventive chelate can be used in X-ray CT or ultrasonic image contrast.
Owner:CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
Application of aromatic nitro compound in preparing medicine for treating virus hepatitis
InactiveCN101190211APrevent proliferationNo drug resistanceOrganic active ingredientsDigestive systemNitro compoundDisease
The invention relates to a novel application of aromatic nitro compound in the pharmaceutical field, in particular to the application of aromatic nitro compound in treating viral hepatitis. The aromatic nitro compound can be used alone or can be combined with other commonly used anti- viral hepatitis drugs to effectively restrain the replication and secretion of hepatitis virus. The aromatic nitro compound can remarkably restrain the replication and secretion of hepatitis virus in the bodies of mammals. The aromatic nitro compound is especially suitable for treating the diseases caused by hepatitis B virus and hepatitis C. The invention provides the concrete method for treating the patients with hepatitis B and hepatitis C.
Owner:上海富海科星咨询管理有限公司
Medicines of different characters and their prepn and use
InactiveCN1931180AFunction changeExtensive nutrient metabolism regulationPowder deliveryOrganic active ingredientsVascular diseaseProtein kinase activation
The present invention is dibutyrul adenosine cyclophosphate calcium and its hydrate in the molecular formula of C18H23N5O8P.1 / 2Ca.nH2O, where n=0-2 5 of different characters. Dibutyrul adenosine cyclophosphate calcium is slightly soluble in water at room temperature and insoluble in ethanol and has high storage stability. Dibutyrul adenosine cyclophosphate calcium and its hydrate are used as protein kinase activator for treating cardiac and cerebral vascular diseases mainly as well as in regulating growth of mammals.
Owner:刘力 +1
Application of hepatitis B surface antigen-antibody complexes in preparing prophylaxis product with no response or low response to hepatitis B vaccine
ActiveCN1919341AEffective infectionProtection from infectionDigestive systemAntiviralsSerum igeHepatitis A vaccine
The invention discloses a new utility of hepatitis B surface antigen-antibody compound in the hepatitis B vaccine non-respond or low-respond prevention agent, which is characterized by the following: purifying recombined HBsAG or inactivated serum HBsAG in the mammal cell, adopting hepatitis B with antibody serum or vaccine globulin as compound, improving anti-HBs ability for non-respond or low-respond mouse.
Owner:FUDAN UNIV +1
Rhizoma dryopteris crassirhizomae and fructus crataegi composition, preparation method and application of composition
ActiveCN102813713ARaw materials are easy to getLow costAntiviralsPteridophyta/filicophyta medical ingredientsPoultry diseaseDisease
The invention relates to a rhizoma dryopteris crassirhizomae and fructus crataegi composition, a preparation method and an application of the composition. The effective components of the composition provided by the invention are prepared from the following raw materials by weight: 10-90 parts of rhizoma dryopteris crassirhizomae and 10-90 parts of fructus crataegi. The rhizoma dryopteris crassirhizomae and fructus crataegi composition provided by the invention is good in effect of preventing and treating poulty viral diseases, in particular to the poultry diseases caused by bursal disease viruses, the poultry kidney diseases caused by renal type infectious bronchitis viruses, the influenza virus A diseases of mammals caused by avian influenza viruses and the poultry avian influenza virus diseases; and the rhizoma dryopteris crassirhizomae and fructus crataegi composition provided by the invention has the characteristics of being more liable to obtain the raw materials, good in curative effect, free of residues, green and environment-friendly and the like, so that the composition can replace the chemical antiviral drugs.
Owner:CHINA AGRI UNIV
Geranium oil and constituents thereof for treatment of neurodegenerative diseases
The invention relates to the use of effective amount of Pelargonium graveolens essential oil or extract or constituents thereof selected from a group consisting of: (S)(-)citroneIlol, linalool, menthone and isomenthone or any combination thereof, in the preparation of a medicament for treating a mammal suffering from or susceptible to a neurodegenerative condition which can be improved or prevented by inhibition of acetylcholinesterase (ACliE).
Owner:以色列国家农业和农村发展部农业科研组织(ARO)(沃尔卡尼中心)
Extract from oil palm leaves comprising phenolic acids
InactiveCN102123720AReduce or avoid oxidative stressSenses disorderNervous disorderGallic acid esterOxidative stress
Provided is a composition comprising an extract from oil palm leaves characterized in that the extract comprises (-)-catechin gallate, ferulic acid, and phenolic acids such as gallic acid and protocatechuic acid and a method for producing said extract comprising the steps of (a) extracting the dried or fresh oil palm leaves with a solvent, (b) filtering the extract obtained in (a), (c) contacting the filtered extract from (b) with an chromatographic medium which selectively adsorbs a fraction containing (-)-catechin gallate, ferulic acid, and phenolic acids, (d)eluting the said fraction from the chromatographic medium using a solvent, (e) drying the eluted fraction obtained in step (d). Also claimed is the use of the composition for reducing or preventing oxidative stress in mammals and poultry.
Owner:NOVARTIS AG
Cognitive map construction method based on space and motion joint coding
ActiveCN110019582AStable codingHigh biological fidelityBiological neural network modelsGeographical information databasesVisual perceptionPositioning system
The invention relates to a cognitive map construction method based on space and motion joint coding, and belongs to the technical field of robot navigation. A sniffing layer-hippocampus neural circuitin an internal positioning system of the brain of a mammal is considered; a continuous attractor neural network model-spatial memory network is formed by utilizing spatial navigation coding characteristics of position cells, head orientation cells, grid cells and velocity cells, space and motion characteristics of animals are coded at the same time, and path integration is carried out on angularvelocity and linear velocity. In the network, the asymmetric connection weights among the neurons generate system inherent activity peaks capable of spontaneously moving, once speed input exists, theattractor network can steadily integrate the linear speed and the angular speed, and stable robot head direction and position coding is formed. And local view cells are formed through single-camera visual input, so that the accumulative error of path integration can be corrected. According to the invention, a consistent half-meter topological map can be stably constructed by using a single camera.
Owner:SHENYANG INST OF AUTOMATION - CHINESE ACAD OF SCI
Method and composition for protection against radiation
InactiveCN101478982AAvoid damagePeptide/protein ingredientsAntinoxious agentsMedicineArginine degradation
Methods are described for using an arginine depleting agent such as arginase and derivatives thereof, which reduce physiological arginine levels, as radioprotectants to protect normal mammalian cells from DNA damage caused by ionizing radiation. Treatment can result in the protection of normal tissues in cancer patients undergoing radiotherapy and in protection from the hazardous effects of exposure to radiological dispersal devices or occupational and environmental ionizing radiation.
Owner:BIO CANCER TREATMENT INT
Integrated mammalian hypoxia experiment simulation device and method
InactiveCN104799967BEasy to useLarge air pressure adjustment rangeDiagnosticsSurgeryVacuum pressureAutomatic control
The invention discloses an integrated hypoxia experiment simulation device and a method of mammals. The integrated hypoxia experiment simulation device comprises a processor module; the processor module is connected with a display module, a setting module, a sensor module, a power module and a control module; the control module is connected with a vacuum pump. The integrated hypoxia experiment simulation device provided by the invention has the characteristics of being compact in structure and convenient to use; besides; the device can automatically control vacuum pressure, reduce the operating difficulty of students making experiments, and enable the students to mainly focus on the observation of the hypoxia phenomenon, so that the experiment efficiency is greatly enhanced, and the experiment effect is improved; moreover, the experimental device is stable in experiment effect, high in repeatability and good in effect of experiment teaching.
Owner:SHANDONG UNIV
Polysaccharide-containing composition and lacrimal fluid layer-stabilizing instillation
An object of the present invention is to provide a composition which is excellent in safety and capable of dispersing uniformly on the mucous tissue when topically administered to mammals, and an ophthalmic soulution comprising the composition and capable of stabilizing the tear film and keeping the rear film on the eyeball surface snooth. In a composition comprising a polysaccharide, particularly agar, and water as essential components, an ophthalmic solution comprising the agar-containing composition of which an amount of precipitated agar after performing centrifugal separation at with 40,000 xg is less than 65 wt% of a total agar content has an excellent tear film stabilizing effect which was proved by a test on changes of corneal surface irregularity. Therefore, the agar-containing ophthalnic solution of the present invention has the effect of stabilizing the tear film on the eyeball surface over a prolonged period of time and is usable as an artificial tear fluid.
Owner:TORAY IND INC
Universal operative dissecting table for mammals
InactiveCN105919763AEasily pull awayConvenient viewing in all directionsOperating tablesEngineeringPlain bearing
Owner:HUANGHE S & T COLLEGE
Maternal inheritance of acquired character -phenotype of acquired character test animal model test method
The invention discloses a maternal inheritance of acquired character -phenotype of acquired character test animal model test method and relates to the fields of life science and medicines. The invention provides a test animal model method capable of breeding-cultivating higher mammals with spontaneous diseases applied to simulating human diseases. The descendant test animals with metabolic syndrome-hyperglycemia and diabetes mellitus are obtained by feeding gestational mother animals with high-energy feed and are applied to contrast experiment detection / analysis to obtain a biological energy metabolism regulation and control pathogenesis mechanism and a treatment mechanism of human metabolic syndrome-hyperglycemia, diabetes mellitus, obesity and the like, develop new generation treatment medicines and guide clinical intervention treatment. Existence of 'inheritance of acquired character' is confirmed, so that the conventional modern biological foundation / applied science theory method is overturned fundamentally and completely.
Owner:叶新新
In-vitro culture and passage method of buffalo spermatogonial stem cell-like cells
InactiveCN109402045AHigh purityIncrease the number ofCell dissociation methodsCulture processPhosphateMammal
The invention discloses an in-vitro culture and passage method of buffalo spermatogonial stem cell-like cells. The in-vitro culture and passage method comprises the following steps: putting primary buffalo spermatogonial stem cell-like cells into a culture dish containing buffalo supporting cells; culturing for 60 to 120 h to finish in-vitro culture; adding a PBS (Phosphate Buffer Solution) into the buffalo spermatogonial stem cell-like cells obtained by the in-vitro culture; collecting superficial cells; adding a pancreatin cell digestive juice into the superficial cells and digesting for 10to 60 s; then adding an IMDM (Iscove's Modified Dulbecco's Medium) culture solution to stop enzymic digestion reaction; collecting superficial cells and transferring the superficial cells which are collected at the second time into a culture dish paved with gelatin; culturing for 1.5 to 4 h; taking supernatant cells and transferring into a feeder layer containing the buffalo supporting cells to finish passage culture. The in-vitro culture and passage method provided by the invention is simple and convenient to operate, safe and reliable and high in repeatability, and has great significance ontreatment of infertility of mammals and protection of endangered species resources.
Owner:卢克焕 +1
Integrated hypoxia experiment simulation device and method of mammals
InactiveCN104799967AIntuitive behaviorIntuitive body surface changesDiagnosticsSurgeryVacuum pressureAutomatic control
The invention discloses an integrated hypoxia experiment simulation device and a method of mammals. The integrated hypoxia experiment simulation device comprises a processor module; the processor module is connected with a display module, a setting module, a sensor module, a power module and a control module; the control module is connected with a vacuum pump. The integrated hypoxia experiment simulation device provided by the invention has the characteristics of being compact in structure and convenient to use; besides; the device can automatically control vacuum pressure, reduce the operating difficulty of students making experiments, and enable the students to mainly focus on the observation of the hypoxia phenomenon, so that the experiment efficiency is greatly enhanced, and the experiment effect is improved; moreover, the experimental device is stable in experiment effect, high in repeatability and good in effect of experiment teaching.
Owner:SHANDONG UNIV
Application of herba cistanche based phenylethanoid glycosides to anti-depression
InactiveCN109078049AEasy to makeNervous disorderNatural extract food ingredientsReflux extractionTeucrium extract
The invention discloses application of herba cistanche based phenylethanoid glycosides to anti-depression. A herba cistanche total extract or herba cistanche phenylethanoid glycoside extract is applied to preparation of anti-depression medicines for male mammals. The herba cistanche extract is an effective component obtained by subjecting herba cistanche powder to liquid reflux extraction to obtain concentrated liquid and subjecting the concentrated liquid to macroporous adsorption resin column chromatography separation. By the effective component prepared from cistanche deserticola and cistanche tubulosa according to an extraction and separation method, the phenylethanoid glycosides have great anti-depression effects and can be applied to preparation and development of anti-depression preparations.
Owner:SHANGHAI JIAOTONG UNIV
Application of benzoquinone compounds in improving antioxidase expression to suppress pathology phenomena related to inflammations
InactiveCN103655528AIncreased expression of antioxidant enzymesAntibacterial agentsMetabolism disorderHydrogenMammal
Owner:CHINA MEDICAL UNIVERSITY(TW)
Regeneration aid for bone defects
The invention relates to a molded part for supporting bone regeneration, in particular the regeneration of a jawbone or jawbone section in a mammal, preferably a human, wherein the molded part is suitable for applying to the jawbone and has a coating having a composition comprising at least one collagen, a granular material, and hyaluronic acid or a hyaluronic acid derivative. The invention further relates to a granular material that can be used in the coating, to a method for producing the granular material, and to the use of the molded part.
Owner:安东尼·阿莱克斯
Donkey-hide gelatin containing black-bone sheep and preparation method of donkey-hide gelatin containing black-bone sheep
InactiveCN105876797ARich in melaninHas dual health functions of nourishing yin and nourishing yangFood scienceRadix AconitiIn vivo
The invention provides donkey-hide gelatin containing black-bone sheep and a preparation method of the donkey-hide gelatin containing the black-bone sheep. The black-bone sheep is added during preparation of the donkey-hide gelatin, and raw materials include black-bone sheepskin and bones, donkey hide, Radix Angelicae Sinensis, Rhizoma Ligustici Wallichii, Radix Aconiti Carmichaeli and Rhizoma Zingiberis. By combination of high-quality black-bone sheep gelatin and traditional donkey-hide gelatin, selection of the raw materials is in coordination with black donkeys which are superior raw materials of the donkey-hide gelatin, and the black-bone sheep which is rich in melanin has dual healthcare functions of Yin nourishing and Yang tonifying, is the only known mammal high in in-vivo melanin content and has extremely high medicinal and healthcare values. The black-bone sheep gelatin and the donkey-hide gelatin are compatible and complementary, quality and nutrition of the traditional donkey-hide gelatin are improved, deep development of related black-bone sheep products is greatly promoted, black-bone sheep breeding and industrial development can be promoted, and local economy is promoted substantially.
Owner:李金明 +1
Skin osmosis promoting absorbing agent of cryptotanshinone
InactiveCN101254165AQuick effectGood anti-inflammatory effectAntibacterial agentsOrganic active ingredientsSide effectIrritation
The invention discloses a cryptotanshinone cutaneous penetration-enhancing absorbent aiming to realize the percutaneous absorption of cryptotanshinone through carrying by 1-dodecylazacycloheptan-2-one, which is used for treating body surface suppurative inflammation of mammals caused by staphylococcus aureus, pseudomonas aeruginosa and hemolytic streptococcus. The preparation method of the absorbent comprises the steps of dissolving 2g cryptotanshinone in 100ml 65% dimethyl sulfoxide aqueous solution heated to 45 DEG C under ultrasonic vibration; adding 5g 1-dodecylazacycloheptan-2-one into the obtained mixed solution under ultrasonic vibration, and mixing; and diluting to 2mg / ml with double distilled water (using cryptotanshinone as reference). The cryptotanshinone cutaneous penetration-enhancing absorbent has the advantages of quick action, good antiphlogistic effect, low irritation, and low side effects.
Owner:TAISHAN MEDICAL UNIV
Brainlike robot navigation method based on Bayes multi-mode perception fusion
ActiveCN109425340AStable codingHigh biological fidelityNavigational calculation instrumentsNavigation by speed/acceleration measurementsMammotrophNeuron
The invention relates to a brainlike robot navigation method based on Bayes multi-mode perception fusion. The brainlike robot navigation method based on Bayes multi-mode perception fusion comprises following steps: integration cells are subjected to vestibular information fusion; integration cell spike rate is changed based on obtained vestibular information; calibration cells are subjected to visual sense information fusion; grid cell network and head direction cell network are subjected to energy injection, and integration cell and calibration cell spike rates are changed; comprehensive inhibition is carried out; and the phases of the spike rates of the grid cell network and the head direction cell network are estimated so as to obtain the current robot practical position and head direction; and a topological map is constructed. A model disclosed in the invention can be used for multi-mode perception fusion, realizing stable coding on robot space environment and robot self states; the head direction neuromechanisms of the model and mammals are the same, the results are similar to mononeuron recorded experiment results acquired in neurobiology, and extremely high biological fidelity is achieved.
Owner:SHENYANG INST OF AUTOMATION - CHINESE ACAD OF SCI
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