63 results about "Methoxymethylbenzene" patented technology

Oral care compositions having improved taste, said compositions comprising: a carrier material; from about 0.001 to about 10%, by weight of the composition, of an oral care component selected from metal salts, antimicrobial agents, bad breath reduction agents, bleaching agents, surfactants, or a combination thereof; and from about 0.0001 to about 1%, by weight of the composition, of a TRPA1 agonist selected from vanillin esters; benzoate esters; hydroxybenzoate derivatives; methoxy benzoate derivatives; hydroxybutanedioate derivatives; benzamidobenzoate derivatives; methylpropanoate derivatives; phenyl acetate derivatives; hex-3-enoate derivatives; 2-(furan-2-ylmethylsulfanyl)-3-methylpyrazine; phenylmethoxymethylbenzene; (2R)-2-azaniumyl-3-[(2R)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3E)-2-hydroxy-4,8-dimethylnona-3,7-dienal; (2R)-2-azaniumyl-3-[(2S)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3Z)-3-butylidene-2-benzofuran-1-one; 3-methyl-N-(3-methylbutyl)butan-1-imine; 2-(furan-2-ylmethyldisulfanylmethyl)furan; and combinations thereof. Uses thereof and methods of improving the taste of an oral care composition.

An oxidative hair colorant composition to be dispensed from a manually-actuable, non-aerosol dispenser as a foam. The oxidative hair colorant composition contains the free-base of 1,4-diamino-2-methoxymethyl benzene to achieve for efficient dye precursor levels in formulation and to achieve a desire rheology profile of the oxidative hair colorant composition.

Disclosed is a method of making 2-methoxymethyl-1,4-benzenediamine that includes hydrogenating 1-benzylamino-2-(methoxymethyl)-4-nitrobenzene in the presence of a hydrogenation catalyst.

The invention belongs to the technical field of molecular probes, in particular to a luminescent carbon quantum dot, a preparation method and application thereof, and a method for detecting arginine in an aqueous solution by using the luminescent carbon quantum dot, in particular to a method for synthesizing the carbon quantum dot by using 2-methoxy-4-methylphenol and o-phenylenediamine as raw materials by a hydrothermal synthesis method and detecting arginine by fluorescence. The synthesis cost of the carbon quantum dot is low, the method is simple, the synthesized carbon quantum dot does notcontain heavy metals, and has low toxicity, and the carbon quantum dot provided by the invention is completely water-soluble, and can detect arginine in water, the detection limit is 78.11 mu M, thefluorescence quantum yield in water is 6.3%, and the luminescent carbon quantum dot has very good light stability, anti-interference and relatively good application prospects.

The invention discloses a supported nickel-cobalt bimetallic nano-catalyst and an application of the supported nickel-cobalt bimetallic nano-catalyst in catalyzing a selective hydrogenation reaction of vanillin. On the basis of a special pore channel structure of MOF, nickel is introduced for structural modulation, then metal is reduced at a high temperature by using a carbon source of the MOF to form a carbon-loaded and coated metal structure, and the alloy is coated with a carbon layer by further combining with glucose carbonization, so that the bimetallic nickel-cobalt alloy nano-catalyst with a double-carbon-layer protection structure is constructed; and the structure can prevent oxidation and dissolution of metal particles, and the stability of the catalyst is greatly improved. The prepared bimetallic nickel-cobalt alloy nano-catalyst is novel and unique in structure, high in stability and high in catalytic activity; and when the bimetallic nickel-cobalt alloy nano-catalyst is applied to a reaction for preparing 2-methoxy-4-methylphenol through selective hydrogenation of vanillin, the conversion rate of vanillin reaches 90-100%, and the selectivity of 2-methoxy-4-methylphenol reaches 90-100%.

An oxidative hair colorant composition to be dispensed from a manually-actuable, non-aerosol dispenser as a foam. The oxidative hair colorant composition contains the free-base of 1,4-diamino-2-methoxymethyl benzene to achieve for efficient dye precursor levels in formulation and to achieve a desire rheology profile of the oxidative hair colorant composition.

The invention provides a minjiang lily spice composite as a new-type lily spice composite which is characterized in that: at least one of jasmal, geranyl acetate, terpene-4-ethanol, dimethoxy methyl benzol, methyl anthranilate and anisyl acetate is added in a base composite based on the lily spice, further comprising at least one spice regulator of triethyl citrate, diisobutyl adipate, tetrahydrophthalic anhydride abietic acid methyl ester and Dihydrogenated abietic acid methyl ester.

The invention relates to a process for preparing 2,3-dimethoxy-5- methyl-1,4- benzophenone (I) by subjecting raw material 3,4,5-trimethoxytoluene (II) first with phosphorus oxytrichloride and N,N-dimethyl formamide to Vilsmeier reaction, obtaining 2,3,4-trimethoxyl-6- methyl- benzaldehyde (III) by introducing aldehydo onto phenyl ring, and oxidizing (III) into phenol (IV) with H2O2 at the presence of small amount organic acid catalysis at room temperate.

Disclosed are methods and compositions for reducing toxicity associated with infection by Clostridium difficile by inhibiting Clostridium difficile toxin B (TcdB) and / or toxin A (TcdA). Such compounds include ebselen compounds, namely ebselen and its salts, ebselen functional analogues and ebselen structural analogues, as well as certain amide derivatives. This includes Formula I, e.g. 1-methyl-3-phenylpropylamine, Formula II, e.g., 2,2′-diselane-1,2-diylbis[N-(2,4-difluorophenyl)benzamide]; and Formula III, e.g. 2-(2-methoxy-5-methylphenyl)-1, 2-benzoselenazol-3-one. The present compositions may be comprised in a colon-retentive formulation that increases residence of and / or release of the compound in the area where the infection is active.

The invention relates to a medicinal composition for inhibiting angiogenesis and application thereof. The medicinal composition comprises any one composition of 2-methoxy-6-methyl-P-benzoquinone(2-methoxy-6-methyl-p-benzoquinone), 2,3-dimethoxy-5-methyl-P-benzoquinone(2,3-dimethoxy-5-methyl-p-benzoquinone) or 2-hydroxy-5-methoxy-3-methyl-P-benzoquinone(2-hydroxy-5-methoxy-3-methyl-p-benzoquinone) and appropriate pharmaceutically acceptable excipients or supporting agents; and the medicinal composition is used for inhibiting the angiogenesis and further treats or prevents angiogenesis-related diseases.

The invention relates to a compound (III) which is the crystalline form of [4-{[4-amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,1-f] [ 1,2,4]triazin-7-yl]methyl}piperazin-2-one hydrochloride] which is a monohydrate, processes for preparation thereof, pharmaceutical compositions comprising the same and its use in the control of disorders, including cancer.

The invention relates to a Si-H polymer, a heat-conducting silica gel composition and a preparation method and application of the Si-H polymer and the heat-conducting silica gel composition. The Si-H polymer is obtained by carrying out condensation polymerization on hydrogen-containing silane containing 2 to 3 methoxy groups, methyl phenyl diethoxy silane and diphenyl silanediol; the molar ratio of the methoxy group in the hydrogen-containing silane to the diethoxy group in the methyl phenyl diethoxy silane to the hydroxyl group in the diphenyl silanediol is 1: (0.5-1.5): (0.25-1). The Si-H polymer is used as a cross-linking agent to be added into the components of the heat-conducting silica gel, so that the oil leakage problem of the cured heat-conducting silica gel can be effectively improved, and meanwhile, no obvious negative influence is brought to the flexibility of the heat-conducting silica gel. In addition, the oil leakage problem is effectively improved, so that the heat-conducting property of the heat-conducting silica gel is kept stable for a long time.

The invention discloses a 2-methoxy-4-methylphenol preparation method based on vanillin selective hydrodeoxygenation, which comprises the following steps: adding a reactant vanillin into a reaction kettle containing a certain amount of solvent, and carrying out hydrodeoxygenation reaction in the presence of a catalyst to obtain 2-methoxy-4-methylphenol, the catalyst is a porous carbon nanosphere loaded with a metal active component, the expression of the catalyst is M (at) CNS, M is any one of metal ruthenium, platinum, palladium, iridium, rhodium and gold, and CNS is a porous carbon nanosphere carrier. The porous carbon nanosphere not only has the characteristics of large specific surface area, abundant shell pore channels and easy regulation and control of pore diameter, but also has high dispersity and uniform size of loaded metal nanoparticles. The catalyst can realize high-efficiency and high-selectivity hydrodeoxygenation of vanillin under mild conditions to prepare 2-methoxy-4-methylphenol.

The invention provides a preparation method for tefuryltrione, and belongs to the technical field of compound preparation. The preparation method comprises the following steps that esterification reaction is carried out on 2-chloro-3-methyl-4-methylsulfonylbenzoic acid serving as a raw material and methanol so as to generate methyl 2-chloro-3-methyl-4- methanesulfonylbenzoate; then reaction is carried out with N-bromosuccinimide to replace one hydrogen in a methyl group on a benzene ring so as to generate methyl 2-chloro-3-methyl bromide-4-methanesulfonylbenzoate; then a product of methyl 2-chloro-4-(methylsulfonyl)-3-(((tetrahydrofuran-2-yl)methoxy)methyl) benzoate is synthesized by using a Williamson synthesis method; and then condensation reaction is carried out with cyclohexanedione under the action of ethylene diamine so as to generate enol ester, and finally, acetonitrile is added for rearrangement catalysis under the action of the ethylene diamine so as to obtain a target product of the tefuryltrione. The preparation method has the advantages of being mild in reaction conditions and simple in synthesis steps.

The invention discloses a synthesis method of DPA. The method comprises the following steps: (1) adding methanol, o-nitrotoluene, a catalyst, concentrated sulfuric acid, distilled water into an autoclave, performing heating with stirring to 50 DEG C, evacuating air and then introducing hydrogen, controlling a pressure in the autoclave to 0.1 MPa, carrying out a reaction for 5 h, then performing suction filtration, distilling a filtrate to remove methanol, diluting a residual solution by adding water and then adjusting pH to be neutral with ammonia water, performing extracting with toluene, washing an organic phase with a dilute sodium hydroxide solution, and performing reduced pressure distillation on the organic phase to obtain 4-methoxy-2-methylaniline; and (2) adding 4-methoxy-2-methylaniline, phenol naphthalene, cyclohexanone, and the catalyst into an autoclave, replacing air with nitrogen, performing heating to 250 DEG C, controlling a pressure in the autoclave to 1 Mpa, performing cooling to room temperature after a reaction is completed, filtering a reaction solution, and performing reduced pressure distillation on a filtrate and collecting various fractions, wherein a latter fraction is DPA. The raw materials are cheap and easy to obtain, the operation is simple, the yield is high, the energy consumption is low, and the method has practical value and economic value, andis suitable for enterprise production.

The invention discloses a method for synthesizing 2,3,5,6-tetrafluoro-4-methoxymethyl benzyl alcohol through 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene and belongs to the technical field of organic synthesis. The method comprises the following steps: taking the 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene to react in a mixed solution composed of a sulfuric acid water solution and organiccarboxylic acid; carrying out ester group hydrolysis reaction on an obtained mixture under the action of inorganic alkali; carrying out methylation reaction of hydroxyl under the action of the inorganic alkali; finally, separating and purifying to obtain the 2,3,5,6-tetrafluoro-4-methoxymethyl benzyl alcohol and recycling the 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene. According to the method provided by the invention, resource utilization of the low-value 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene is realized; meanwhile, the method has the advantages of cheap and easy-to-obtain reaction reagents, moderate reaction conditions, simplicity in operation, high synthesis yield, good product quality and the like, and has very high social and economic value.

By reacting 3-methyl-2-methoxymethylaniline, etc. with a phosgene compound in the presence of a tertiary amine at 10° C. to 14° C. in at least one kind of solvent selected from a group consisting of chlorobenzene and ortho-dichlorobenzene, an isocyanate compound such as 3-methyl-2-methoxymethyl-1-isocyanatobenzene can be manufactured with good yields.

The invention discloses a purifying method of N-(3-methoxy-2-methyl benzoyl)-N'-tert-butylhydrazine. The purifying method comprises the steps as follows: adding water and acid to reaction product obtained by reaction of 3-methoxy-2-methyl benzoyl chloride and tert-butylhydrazine to carry out acidizing until pH is less than 3; keeping the hydrolysis temperature of 40 to 105 DEG C, and hydrolyzing for 0.5 to 5 hours for hydrolyzing the byproduct; filtering to remove 3-methoxy-2-methyl benzoic acid; adding alkali to the obtained mother liquor to carry out alkalizing; adjusting pH to 7 to 12; and filtering to obtain the high-purity product N-(3-methoxy-2-methyl benzoyl)-N'-tert-butylhydrazine. The purifying method disclosed by the invention is simple in production, and greatly improves the purity of the product; and moreover, the expensive intermediate 3-methoxy-2-methyl benzoic acid can be recycled, so that the producing cost is reduced; and little three wastes are produced during the processing; and the purifying method is beneficial to environmental protection, and is suitable for industrial production.

The invention relates to a preparation method for idebenone, comprising the following steps: (1), 3,4,5-trimethoxy-toluene has friedel-crafts reaction with 10-acetoxy-decane chloride or 10-acetoxy-decanoyl- bromine to generate 6-(10-acetoxy-1-oxo-decane yl)-2,3-dimethoxy-5-methyl phenol; (2), the 6-(10-acetoxy-1-oxo-decane yl)-2,3-dimethoxy-5-methyl phenol obtained in the step (1) is reacted withhydrogen under the joint effect of palladium-carbon catalyst and dehydrating agent DCC to generate 6-(10-acetoxy-decyl)-2,3-dimethoxy-5-methyl phenol; (3), the6-(10-acetoxy-decyl)-2,3-dimethoxy-5-methyl phenol prepares 6-(10-hydroxy decyl) -2,3-dimethoxy-5-methyl phenol through hydrolysis; (4), the 6-(10-hydroxy decyl) -2,3-dimethoxy-5-methyl phenol has oxidation reaction with an oxygen-supply body under the effect of catalytic oxidizer Cu (Salen) so as to generate the idebenone. The preparation method has low cost and high yield, which is suitable for large-scale industrial idebenone production.

The present invention provides an excellent pest-controlling agent. The agent holds 2,3,5,6-tetrafluoro-4-methoxymethylbenzyl 3-(2- methyl-1-propenyl)-2,2-dimethylcyclopropane carboxylate as an active ingredient on dry plants.

Analogs of (4aS,6R,8aS)-5,6,9,10,11,12-hexahydro-3-methoxy-11-methyl-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol of the formula:whereinR1 carbamate, carbonate or carboxlate group;R2 is alkoxy group of from one to six carbon atoms, a hydroxy group, hydrogen, an alkanoyloxy group or 2 to 10 carbon atoms, a benzoyloxy or substituted benzoyloxy group, a carbonate group of 1 to 10 carbon atoms or a carbamate group such as a mono alkyl or dialkyl or an aryl carbamate wherein the alkyl groups or aryl groups contain from 1 to 10 carbons; andR3 is hydrogen, alkyl of 1 to 10 carbon atoms, benzyl, cyclopropylmethyl group or a substituted or unsubstituted benzoyloxy group are of use in treating persons meeting criteria for having a risk of developing Alzheimer's type dementia, before symptoms of dementia are observed by reducing the decline of Aβ amyloid CSF.

The invention provides a method for preparing 2-methoxy-4-methylphenol from biomass-based vanillin and a preparation method of the 2-methoxy-4-methylphenol. According to the method, vanillin, a catalyst and a solvent are added into a reaction kettle, chemical reaction is carried out in the reaction kettle to obtain the required 2-methoxy-4-methylphenol, the catalyst is a nitrogen-doped hollow carbon sphere loaded non-noble metal Co catalyst, the main structure of the catalyst is a hollow carbon sphere, the hollow structure is used as a carrier, and the carrier is used as a solvent. Metal particles are loaded on the carrier, and the surface of the carrier has a mesoporous structure, so that a unique confinement effect can be provided for hydrodeoxygenation reaction of vanillin, the metal nanoparticles can be stabilized, the stability of the catalyst can be improved, meanwhile, strong metal-carrier interaction can be formed, and the electronic property of the metal surface can be effectively changed; furthermore, adsorption and activation of vanillin and an intermediate vanillyl alcohol on the surface of the catalyst can be enhanced, and the selectivity of preparing 2-methoxy-4-methylphenol by hydrodeoxygenation of vanillin is improved.

The invention discloses a purifying method of N-(3-methoxy-2-methyl benzoyl)-N'-tert-butylhydrazine. The purifying method comprises the steps as follows: adding water and acid to reaction product obtained by reaction of 3-methoxy-2-methyl benzoyl chloride and tert-butylhydrazine to carry out acidizing until pH is less than 3; keeping the hydrolysis temperature of 40 to 105 DEG C, and hydrolyzing for 0.5 to 5 hours for hydrolyzing the byproduct; filtering to remove 3-methoxy-2-methyl benzoic acid; adding alkali to the obtained mother liquor to carry out alkalizing; adjusting pH to 7 to 12; and filtering to obtain the high-purity product N-(3-methoxy-2-methyl benzoyl)-N'-tert-butylhydrazine. The purifying method disclosed by the invention is simple in production, and greatly improves the purity of the product; and moreover, the expensive intermediate 3-methoxy-2-methyl benzoic acid can be recycled, so that the producing cost is reduced; and little three wastes are produced during the processing; and the purifying method is beneficial to environmental protection, and is suitable for industrial production.

The invention discloses a salt-fog-resistant silver-plated aluminum powder conductive coating and a preparation method thereof, and belongs to the technical field of conductive coating preparation. Aluminum powder is placed in a 2-methoxy-4-methylphenol aqueous solution for a surface modification reaction, a modified product is washed and then dried, and reduced aluminum powder with the surface coated with a reduction layer is prepared; the obtained reduced aluminum powder is subjected to surface activity treatment washing through a silver source, and activated aluminum powder with elemental silver on the surface is obtained after an active product is washed; the obtained activated aluminum powder is subjected to chemical silver plating treatment, and silver-plated aluminum powder is prepared; graft modification is conducted on the silver-plated aluminum powder by adopting perfluorodecanethiol to obtain a grafted product, and the obtained grafted product is washed and dried to obtain modified silver-plated aluminum powder; and the obtained modified silver-plated aluminum powder is sprayed on a coating substrate to obtain a coating, and the obtained coating is dried to obtain the salt-fog-resistant silver-plated aluminum powder conductive coating. The preparation method is simple to operate and low in cost, and the obtained product is excellent in salt spray corrosion resistance and has expanded-scale production value.

The invention provides a preparation method of a key intermediate compound 1-(2-halogeno)-2-methyl-butanone-1 for the synthesis of an oral antidiabetic medicament Repaglinide, belonging to the field of organic chemical synthesis. The preparation method comprises the following steps: under the action of phosphorus trichloride, preparing 2-halogenobenzoic acid and N-methoxy methylamine used as raw materials into 2-halogeno-N-methoxy-N-methyl benzamide in anhydrous methylbenzene used as solvent; and then, further reacting with magnesium isobutyl bromide under the protection of nitrogen gas for 2-3 hours, separating, and purifying to obtain the target compound 1-(2-halogenophenyl)-3-methyl-butanone-1. The preparation method provided by the invention has the advantages of accessible raw materials, simple process, short reaction scheme, low cost and high efficiency; the reaction is performed at room temperature, the reaction conditions are mild, no catalyst is used, and few subsidiary reaction exists in the reaction, thereby ensuring that the preparation method is green and environment-friendly; and the target product yield is high (up to 80% or above), and the product quality is high (the purity is above 99%). Thus, the preparation method is beneficial to industrial production.

The present invention provides a method for detecting the saponinols in sassafras plants or extracts. The method adopts gas chromatography-mass spectrometry to measure sassy phenols in sassafras plants or extracts. The sample tube containing water-removing agent anhydrous magnesium sulfate is used to collect the plants or extracts of S. japonica, add 1-10mL of methanol solution and shake fully for 10-30min, then take 1-2mL of the extraction solution into the chromatographic bottle, seal it quickly, and pass through the gas chromatography. ‑Mass spectrometry analysis, external standard method for quantification; this detection method is suitable for 3,4‑dimethylphenol, 3‑methoxy‑5‑methylphenol, 3‑methoxy 2,5,6-trimethylphenol, 3,5-dihydroxytoluene, 2,5-dihydroxytoluene, 5-methoxy-2,3-xylenol, 2,5-dimethyl Simultaneous detection of ‑1,4‑benzenediol and other dendrols has the advantages of rapidity, accuracy, and simple operation.

The invention discloses a synthesis process of 2-methyl-3-methoxybenzoic acid, which comprises the following steps: (1) reductive hydrogenation reaction: by taking 2-methyl-3-nitrobenzoic acid or methyl 2-methyl-3-nitrobenzoate as a raw material, methanol as a solvent, hydrogen as a hydrogen source and palladium on carbon or platinum on carbon as a catalyst, carrying out hydrogenation reduction to prepare 3-amino-2-methyl benzoic acid or methyl 3-amino-2-methyl benzoate; (2) diazotization, hydrolysis and esterification one-pot reaction: by taking the reduction product as a raw material and methanol as a solvent, under the action of a diazotization reagent, performing diazotization, hydrolysis and esterification reaction to prepare methyl 3-hydroxy-2-methyl benzoate; (3) methylation reaction: by taking methyl 3-hydroxy-2-methyl benzoate as a raw material and dimethyl sulfate as a methylation reagent, carrying out methylation reaction in the presence of alkali to prepare methyl 3-methoxy-2-methyl benzoate; and (4) hydrolysis reaction: mixing the methyl 3-methoxy-2-methyl benzoate with alkali and water, conducting heating for hydrolysis, conducting cooling after the reaction is completed, adjusting the pH value to 1-3 by using acid, separating out a product, conducting filtering, and conducting drying to obtain 3-methoxy-2-methyl benzoic acid.

The invention relates to a preparation method of idebenone. The method comprises the following steps: adding an oxidant hydrogen peroxide to coenzyme Q0 and 11-hydroxyundecanoic acid used as raw materials and copper chloride, copper sulfate, copper acetate, silver carbonate, silver oxide, palladium chloride or palladium acetate used as a catalyst under the protection of oxygen, and carrying out a free radical alkylation reaction; and carrying out extraction, water washing, drying, reduced pressure distillation and column chromatography on the obtained reaction system to obtain a yellow needle-like crystal 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone, that is idebenone. The preparation method has the advantages of simplicity in operation, low cost and high yield, and is suitable for the large-scale industrial production of idebenone.

A pharmaceutical composition containing an FBPase inhibitor and an insulin sensitizer which is 5-[4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione or a pharmacologically acceptable salt thereof; and a method for preventing or treating diabetes mellitus by administering the composition to a human.