47results about How to "Improve depressive symptoms" patented technology

The invention relates to an essential plant fragrance smell area capable of improving depression symptoms and a construction method thereof. The construction method comprises the steps of: selecting at least 10 from 21 essential plants including eucalypt, frankincense, lemon, bitter orange, hibiscus and the like; planting the selected plants according to a certain proportion and number; at the same time, uniformly arranging a certain number of sound systems in the fragrance smell area to create a natural fragrance smell environment capable of making people relax and happy, and raising spirit and improving depression symptoms in aspects of olfaction, vision, audition and the like at last. When the plants in the fragrance smell area grow to a certain stage, people for smelting fragrance can carry out fragrance smell activities in a certain mode for a certain period in fragrance smell area on the premise that the number of the people for smelling fragrance is no larger than the maximum holding capacity of the fragrance smell area. After a certain period of fragrance smell, the depression symptoms of the people for smelling fragrance can be improved obviously.

An ear vagus stimulator is characterized by comprising an ear electrode, a main frame and connection conductive wires; the main frame comprises a shell which is provided with a hook-shaped part in a protruding mode, the surface formed by the inner side face of the hook-shaped part and one side face of the shell together is matched with the outer side face of the ear back of the human body in shape, and therefore the main frame can be hung on the ear back of the human body; the ear electrode comprises an insulation base, an earplug electrode, an auricle electrode and a regulating knob, the earplug electrode plays a role in locating and acts on the ear canal port when the ear vagus stimulator is used, the auricle electrode plays a role in locating and acts on the auricle portion, the earplug electrode is fixedly arranged on the base, and the auricle electrode is connected to the base in a sliding mode; the regulating knob is screwed on the base, so that the auricle electrode is located on the base after sliding in place; the earplug electrode and the auricle electrode are connected to the main frame through the connection conductive wires. The ear vagus stimulator is simple in structure and convenient to carry, convenient and comfortable to operate when used, good in flexibility when used, and capable of adapting to the sizes and inner shapes of different ears.

A portable desktop apparatus that can be easily and stably mounted to a piece of standard exercise equipment, set at a position desired by the user, and used to accommodate a laptop computer or other equipment. The apparatus is lightweight, adaptable, adjustable, made of durable material, and easily broken down for transport. The user of the apparatus may mount the apparatus to exercise equipment such as a treadmill in order to benefit from light exercise while conducting work-related tasks or other business. The user receives health benefits as a result and is able to burn calories while working as opposed to working in a stationary position and having to find other time for exercise, or forfeit the opportunity to exercise. The apparatus is equipped with safety features for improved stability. Proper use of the apparatus may provide long-term health benefits for its users.

The present invention comprises novel methods for the use of compositions comprising 7-keto DHEA for treating psychiatric conditions. These methods include administering an effective amount of a composition comprising 7-keto DHEA in an acceptable carrier, alone or in combination with other psychiatric drugs, such as analgesic agents, anticonvulsants, anti-anxiety agents, antidepressants, anti-panic agents, antipsychotic agents, bipolar agents, psychostimulants to reduce or ameliorate symptoms of a psychiatric condition. This method may be used alone or as an adjunctive treatment for treating a wide variety of psychiatric conditions such as stress disorders, anxiety disorders and depressive disorders.

The invention discloses an anti-depression light-wave instrument and application thereof. The anti-depression light-wave instrument comprises a switch part, a control part and a light source part, wherein the switch part is connected with an adjusting part by the control part; the adjusting part is connected with the light source part; the adjusting part is used for providing 2.3-2.9V of voltage for the light source part; the light emitted by a light source is monochromatic light in visible light. The better wavelength range is 590-630nm of orange light. The invention also discloses the light source of the anti-depression light-wave instrument. The anti-depression light-wave instrument can be used for resisting depression and anxiety. According to the invention, the depressive symptoms are improved and the side effects of pharmaceutical drugs for resisting depression are reduced.

Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

The invention discloses a head cover-type acupuncture point stimulation device for treating depressive sleep disorder by using five-tone mind regulation. The device comprises a main body and a connecting buckle plate, wherein a width adjusting mechanism is connected to the middle part of the main body; two sides of the width adjusting mechanism are provided with a headgear mechanism which is closeto the main body; and the buckle plate is arranged at the middle part of the headgear mechanism. The head cover-type acupuncture point stimulation device for treating depressive sleep disorder keepsa certain distance between the head of a patient and an earmuff mechanism, the patient is connected to a mobile phone APP through a Bluetooth device fixing sleeve, the tunes corresponding to syndrometype are selected, the corresponding brain wave stimulation is carried out on the brain through the different tunes, after the choice of the tunes is finished, the selection of the pulse emitter therapy is carried out and includes time and strength, the pulse wave stimulation is carried out on the corresponding selected acupuncture points, the related brain area is excited, the recovery and the remodeling of the related nerves are promoted, the sleep disorder and the depression symptoms are improved, and the side effect of drugs can be obviously reduced while the effective therapy is carried out.

The present invention comprises novel methods for the use of compositions comprising 7-keto DHEA for treating psychiatric conditions. These methods include administering an effective amount of a composition comprising 7-keto DHEA in an acceptable carrier, alone or in combination with other psychiatric drugs, such as analgesic agents, anticonvulsants, anti-anxiety agents, antidepressants, anti-panic agents, antipsychotic agents, bipolar agents, psychostimulants to reduce or ameliorate symptoms of a psychiatric condition. This method may be used alone or as an adjunctive treatment for treating a wide variety of psychiatric conditions such as stress disorders, anxiety disorders and depressive disorders.

The invention relates to a traditional Chinese medicine composition for treating depression. The composition is mainly prepared from radix bupleuri, radix curcumae, albizia flowers, liquorice, raw keel and oyster, kadsura longepedunculata, ovum of mantis and fructus aurantii. The medicine composition has a good treatment effect on depression caused by various reasons.

The invention relates to the technical field of a system for treating depression based on 3D printing ear molds. The system comprises a nervus auricularis vagi stimulation system, a mobile equipment module, a hospital PC terminal, a maintenance terminal and a cloud server, wherein the nervus auricularis vagi stimulation system comprises a pulse detecting module, a bluetooth module, a state displaymodule, a power supply module, a DC-DC adjustable voltage-increasing voltage-stabilizing module, a first voltage increasing module, a second voltage increasing module, a third voltage increasing module and a data processing module; and the stimulus frequency is 15-30Hz, the output current is 1-10mA ( 250 omega load impedance), the output power is 0.1-0.3VA ( 250 omega load impedance ), the pulsewidth is 0.2ms + / - 30%, and the treatment course is timed to 20-40min. According to the system for treating depression, provided by the invention, stimulus parameters are set, so that data in brain waves and the depression can be well combined for analysis, and the effect of stimulation for treatment is exerted.

A light exposure device (20) for improving cognitive symptoms and depression symptoms is characterized in imparting photostimulation to the retina by continuous flashing of a light source (21) at a frequency of 1 to 10 Hz and by photostimulation, inducing the continuous expression of Homer 1a and activation of the BK-type potassium channels in pyramidal cells of the cerebral cortex. It is possible to realize the same effect as the depression symptom-improving effect of an electroconvulsive stimulation device, and the same effect as the depression symptom-improving effect and cognitive symptom-improving effect of a transcranial magnetic stimulation device, and can be used in a home environment when compared to electroconvusion stimulation devices and transcranial magnetic stimulation devices that are limited being used for treatment at a medical institution.

The invention relates to a traditional Chinese medicine composition for curing depression. The traditional Chinese medicine composition for curing depression is mainly composed of raw materials of Chinese thorowax root, albizia julibrissin, radix glycyrrhizae, acoru tatarinowii, schisandra chinensis, radix aucklandiae and fructus aurantii. The traditional Chinese medicine composition for curing depression has good efficacy for depression caused by various reasons.

An ear vagus stimulator is characterized by comprising an ear electrode, a main frame and connection conductive wires; the main frame comprises a shell which is provided with a hook-shaped part in a protruding mode, the surface formed by the inner side face of the hook-shaped part and one side face of the shell together is matched with the outer side face of the ear back of the human body in shape, and therefore the main frame can be hung on the ear back of the human body; the ear electrode comprises an insulation base, an earplug electrode, an auricle electrode and a regulating knob, the earplug electrode plays a role in locating and acts on the ear canal port when the ear vagus stimulator is used, the auricle electrode plays a role in locating and acts on the auricle portion, the earplug electrode is fixedly arranged on the base, and the auricle electrode is connected to the base in a sliding mode; the regulating knob is screwed on the base, so that the auricle electrode is located on the base after sliding in place; the earplug electrode and the auricle electrode are connected to the main frame through the connection conductive wires. The ear vagus stimulator is simple in structure and convenient to carry, convenient and comfortable to operate when used, good in flexibility when used, and capable of adapting to the sizes and inner shapes of different ears.

The invention relates to the field of medicine, in particular to polypeptide with the effects of stimulating a Sigma-1 receptor, up-regulating the brain-derived neurotrophic factor level and relieving the depressive symptom. The sequence of the polypeptide is a brand-new sequence, and the polypeptide has the advantage of being capable of increasing the BDNF content in chronic unpredictable stress model rat brain tissue. The pharmacological result shows that the polypeptide can relieve the depressive symptom of acute and chronic depression model animals. The polypeptide can serve as an effective candidate treatment method for clinical depression and has potential new medicine development value.

The invention discloses an application of a 1-diphenylmethyl-4-methylpiperazine compound in preparation of an anti-depression drug, and belongs to the field of medicines. The compound 1-diphenylmethyl-4-((1-phenyl-1H-1, 2, 3-triazol-4-yl) methyl) piperazine can significantly improve the depression-like behavior of a chronic unpredictable stress model mouse. Mechanism studies suggest that the compound l-diphenylmethyl-4-((l-phenyl-lH-l, 2, 3-triazol-4-yl) methyl) piperazine can ameliorate mouse intestinal flora disorders induced by a chronic unpredictable stress model; and the compound has a protective effect on the integrity of intestinal barriers and blood-brain barriers.

The invention discloses a mind tranquilizing and sleep helping food and a preparation method thereof and belongs to the technical field of health foods. The mind tranquilizing and sleep helping food comprises the following raw materials: seabuckthorn seeds, spina date seeds, humulone, tuckahoe, mulberries, magnesium orotate and fungus powder; after tuckahoe is added into a humulone organic extract, the humulone organic extract is mixed with an organic extract of the seabuckthorn seeds and the spina date seeds, the mulberries and magnesium orotate are added into an obtained mixture, the funguspowder is added into the mixture to be fermented for 3-5 d after mixing, and then a fermentation product is dried to obtain a finished product. The mind tranquilizing and sleep helping food contains multiple biological active components capable of improving sleeping; the content of vitamin B6 and 5-hydroxytryptamine is obviously increased; the effects of calming, tranquilizing mind and promoting sleep are realized; and by using an antidepressive therapy method, sleep disorders are fundamentally improved, the sleeping quality is improved, and the sleeping time is prolonged.

The present invention provides a combination medicine for treatment of depression, comprising a combination of (A1) an antidepressant and either (B1) a dopamine D1 receptor agonist or (C1) a dopamine D1 receptor antagonist; and a method for screening for an antidepressant that in combination with a dopamine D1 receptor agonist provides an improvement in treatment of depression, the method comprising the steps of: administering, to a mammal, (A2) a compound having an antidepressant action and (B1) a dopamine D1 receptor agonist, and detecting a greater increase in depression-related gene expression, dopamine D1 receptor expression and / or dopamine D1 receptor signaling in comparison with the case where (A2) the compound having an antidepressant action or (B1) the dopamine D1 receptor agonist is administered.

The invention discloses a medicament composition for treating depression, which is a Chinese medicinal preparation mainly prepared from the raw materials such as radix curcumae, hypericum perforatum, puncturevine caltrop fruits and grassleaf sweelflag rhizome. The medicament has the advantages of simple unique prescription, low price and remarkable efficacy. Clinical study confirms that the medicament obviously improves clinical symptoms of depression, decreases the grade of Hamilton Depression Scale (HAM-D) and has the total effective rate of 84 percent. The invention also discloses a method for preparing the medicament. The medicament is obtained by extracting Chinese medicaments with different solvents respectively, performing other pretreatment and then compounding the obtained products pro rata according to the different characteristics of each Chinese medicament.

The invention discloses a traditional Chinese medicine extract with an anti-depression effect and application thereof. 300 to 600 parts of ginseng root, 200 to 400 parts of thinleaf milkwort root, 200 to 400 parts of grassleaf sweelflag rhizome and 300 to 600 parts of Indian bread as active pharmaceutical ingredients are added with water and extracted, and extract is taken out and concentrated, so that concentrate is obtained; the concentrate is purified by a macroporous resin column, water is first used for removing impurities, ethanol of optimal volume is then adopted for elution, so that eluent is obtained, and the traditional Chinese medicine extract is obtained by concentration. Demonstrated by a mouse tail suspension and swimming depression model and PC12 cell and C6 cell models, the traditional Chinese medicine extract provided by the invention has an effect of obviously improving depressive emotion, inhibiting neurotransmitter degradation and promoting neurotrophic factor expression, the therapeutic effect is reliable, safety is high, adverse reaction is low, and the traditional Chinese medicine extract can be used for preparing anti-depression drugs.

The invention relates to application of dihydromyricetin in preparation of a drug for treating depression, the drug comprising the dihydromyricetin can take effect rapidly after being applied, and accordingly, the depression is relieved and treated rapidly.

The invention provides a probiotic composition and its application in the preparation of comorbid constipation and depression medicines, said composition comprising Bifidobacterium animalis subspecies U9, Lactobacillus paracasei L55, Lactobacillus rhamnosus LL23 , Bifidobacterium adolescentis BQ23 and Lactobacillus acidophilus RA15. The present invention has carried out a randomized double-blind test to perform probiotic intervention on depressed patients. A total of 63 depressed patients were recruited, 31 of whom had comorbid constipation. The results showed that after 8 weeks of intervention, the Hamilton depression (HAMD) score of the probiotic group decreased to 14.2±8.0 in the depressed group with comorbid constipation, which was significantly lower than that in the placebo group (22.9±9.9, P<0.05). There was no significant difference in HAMD scores between the population probiotic group and the placebo group. The probiotic composition of the invention can effectively alleviate the depression symptoms of depressed people with comorbid constipation.

The invention relates to the field of medicines, in particular to polypeptide for inhibiting a glucocorticoid receptor and relieving depressive symptoms. The sequence of the polypeptide is SED ID NO:1, which is a brand new sequence. The polypeptide provided by the invention has the beneficial effects that the polypeptide can reduce the glucocorticoid content of chronic unpredictable stress model rat plasma. In-vivo pharmacological results indicate that the polypeptide provided by the invention can improve the depressive symptoms of acute and chronic depression model animals and can serve as an effective candidate treatment method for clinical depression.

The invention relates to a foot-bath traditional Chinese medicine combination for treating after-stroke depression. The foot-bath traditional Chinese medicine combination is prepared by the following raw materials in parts by weight: 25-35 parts of abalone, 25-35 parts of magnetite, 25-35 parts of mother-of-pearl, 25-35 parts of chrysanthemum indicum, 25-35 parts of tuber fleeceflower stem and 25-35 parts of Chinese angelica. The invention also relates to the application of the medicament in preparation of a drug for treating after-stroke depression. Combining with drugs which promote the blood circulation and sooth the liver, the traditional Chinese medicine combination prepared by the invention is capable of obviously improving after-stroke depression symptoms and neurologic deficits of the patient as well as improving ADL ability of the patient, so as to improve the quality of life of the patient. The traditional Chinese medicine combination prepared by the invention utilizes the form of foot-bath to perform treatment, so that the traditional Chinese medicine combination has the advantages of simple method, convenient usage, low liquid medicine cost and no side effect; thus, the foot-bath traditional Chinese medicine combination for treating after-stroke depression has wide application prospect.

The invention provides a ziziphi spinosae semen and bacillus subtilis co-fermentation product and a preparation method and application thereof, and belongs to the technical field of fermentation engineering. The preparation method comprises the following steps of: 1) preparing a bacillus subtilis seed solution culture medium; 2) culturing a bacillus subtilis seed solution; 3) putting the ziziphi spinosae semen powder into a shake flask, adding distilled water, uniformly mixing, and sterilizing to obtain a ziziphi spinosae semen culture medium; 4) inoculating the bacillus subtilis seed solution into the ziziphi spinosae semen culture medium according to 2-10% of the mass of the ziziphi spinosae semen culture medium, putting the ziziphi spinosae semen culture medium into a shaking table, and fermenting for 18-20 hours; and 5) carrying out freeze-drying on a fermentation product, and carrying out crushing and sieving to obtain the ziziphi spinosae semen-bacillus subtilis co-fermentation product. The semen ziziphi spinosae-bacillus subtilis co-fermentation product extract disclosed by the invention has the effect of improving sleep. The ziziphi spinosae semen-bacillus subtilis co-fermentation product can be prepared into medicines for treating insomnia and health-care foods or functional foods for improving the sleep.

The invention belongs to the technical field of medicine and particularly relates to a traditional Chinese medicine composition for treating mind confusion type cardiac neurosis.The traditional Chinese medicine composition is prepared from, by weight, 4-8 parts of finelydivided phtheirospermum roots, 4-8 parts of medical angiopteris rhizome, 4-8 parts of Parish's ironweed, 4-8 parts of common triplostegia roots, 4-8 parts of satyrium henryi schlecht, 4-8 parts of bitter citrus immature flowers, 4-8 parts of nutgrass flatsedge, 4-8 parts of ziziphora clinopodioides lam and 4-8 parts of liquorice roots.The medicinal materials achieve the effects of moisturizing, relaxing tension and tranquilizing mind by nourishing the heart.The traditional Chinese medicine composition can effectively reduce the Hamilton manifest anxiety scale integral and the depression scale integral of patients suffering from mind confusion type cardiac neurosis, and improve the anxiety and depression symptoms of the patients suffering from cardiac neurosis.

The disclosure discloses the application of a 1-benzhydryl-4-methylpiperazine compound in the preparation of antidepressant drugs, which belongs to the field of medicine. The compound 1-benzhydryl-4-((1-benzene 1H-1,2,3-triazol-4-yl)methyl)piperazine can significantly improve the depression-like behavior in chronic unpredictable stress model mice. Mechanistic studies have shown that the compound 1‑benzhydryl‑4‑((1‑phenyl‑1H‑1,2,3‑triazol‑4‑yl)methyl)piperazine can improve the effects of chronic unpredictable stress Induced intestinal flora disturbance in mice; and has a protective effect on the integrity of the intestinal barrier and blood-brain barrier.

The invention discloses application of compound gymnadenia conopsea pills in preparation of a medicine for treating depression so as to overcome technology biases of technology application in the prior art. It is found through animal experiments that the compound gymnadenia conopsea pills help to obviously shorten motionless time of mice in forced swimming and tail-suspension disappointment and depression model experiments and have the same effects as positive drugs. It is found through clinical researches that the compound gymnadenia conopsea pills, separately or used along with fluoxertine hydrochloride, can remarkably improve symptoms of depression and substantially reduce HAMD value, have the same effects as fluoxertine hydrochloride when separately used, and have more excellent effects if used along with fluoxertine hydrochloride.

The invention provides a method for directly preparing aromatic plant active ingredients into solid nano particles without a nano carrier material, and the nano particles prepared by the method. According to the method disclosed by the invention, a nano-carrier material is not needed, so that the active ingredients of the aromatic plants are not restricted by the encapsulation efficiency any more,and finally, the application limitation of the active ingredients of the liquid aromatic plants in a special scene is solved, and the application range of the aromatic plant active ingredients in food, cosmetics, depression symptom improvement, sleep quality improvement and other large health fields is effectively expanded.

The invention relates to an atypical antipsychotic medicinal composition. The medicinal composition contains active components risperidone and sertraline hydrochloride according to a weight ratio of 0.04:1 to 0.08:1, and is applied to the treatment of SCZ when the dosage of risperidone in the active components is 2-4 mg / d. Low-dosage risperidone and sertraline hydrochloride in the medicinal composition have excellent synergistic effects; and compared with medium and high dosage risperidone, the medicinal composition has the advantages of equivalent positive symptom elimination effect, significant elimination of negative symptoms and emotion symptoms, and improvement of the social function of SCZ patients when used in the treatment of SCZ. The medicinal composition greatly reduces the occurrence probability of medium and high dosage risperidone induced hyperprolactinemia, severe extrapyramidal symptoms and other adverse drug events.