Preventing 
skin aging by targeting multiple causes by a single bullet is of primal scientific and 
consumer interest. A treatment based on compositions of compound (I) for 
cellular senescence to control cellular degradation offers such a solution to multiple 
skin ailments including 
skin degradation from 
cancer, diabetes, 
radiation treatments, 
chemotherapy, and sun-burn; mitochondrial dysfunction, age spots, 
acne, loss of cellular antioxidants, collagen loss, loss of skin 
pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from 
radiation, damage from free radicals, damage from UV, 
dry skin, xerosis, 
ichthyosis, 
dandruff, brownish spots, keratoses, 
melasma, lentigines, liver spots, 
pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, 
psoriasis, inflammatory dermatoses, topical 
inflammation, disturbed keratinization, skin changes associated with aging, 
scalp dryness, skin 
depigmentation, 
intracellular dehydration, and combinations thereof;