The invention belongs to the field of traditional Chinese medicines, and particularly discloses application of an 
angelica sinensis-
astragalus membranaceus blood-activating preparation in preparation of a 
medicine for preventing or treating diabetic complications. The 
angelica sinensis-
astragalus membranaceus blood-activating preparation is prepared from thirteen raw medicinal materials including 
astragalus membranaceus, 
angelica sinensis, radix paeoniae alba, radix polygoni multiflori preparata, fructus lycii, mistletoe, 
cornu cervi pantotrichum, rhizoma drynariae, radix clematidis, garden 
balsam stem, musk, radix puerariae and 
ligusticum wallichii, and has the effects of tonifying qi and 
kidney and promoting 
blood circulation to remove meridian obstruction. Pharmacodynamic tests show that the angelica sinensis-astragalus membranaceus blood activating preparation can effectively accelerate the ischial 
nerve conduction speed of diabetic 
peripheral neuropathy model rats, remarkably reduce the serum MDA level of the rats, improve the 
activity level of SOD and GSH-Px, improve the free radical 
scavenging capacity of the organisms and enhance the 
oxidation resistance of the organisms and tissues, so that the rat ischial 
nerve injury is protected and repaired, the 
traditional Chinese medicine composition has an exact 
treatment effect on diabetic 
peripheral neuropathy, is comprehensive in effect and low in toxic and side effects, and has a wide market prospect.