The invention discloses a 
drug delivery system of 
salicylic acid, and a preparation method and application thereof. The 
drug delivery system of the 
salicylic acid is prepared from the following components in percentage by weight: 1 to 5 percent of 
capryloyl salicylic acid, 10 to 30 percent of liquid lipid, 5 to 15 percent of 
solid lipid, 4.5 to 10 percent of interfacial 
active agent, 1 to 5 percent of pentanediol, 0.2 to 2 percent of 
lecithin, and the balance of water. The liquid lipid and the 
solid lipid are mixed to be used as raw materials to embed the 
capryloyl salicylic acid; the 
drug delivery system is characterized in that oil is wrapped with fat which is wrapped with water (O / F / W), and has the characteristics of high 
embedding rate, high drug loading capacity, high stability, low 
irritability and favorable 
drug release characteristic; a cosmetic 
medicine composition prepared by utilizing the 
drug delivery system provided by the invention for embedding the 
capryloyl salicylic acid is beneficial for brightening 
skin, removing dark spots and freckles, whitening 
skin, removing wrinkles, disinfecting, diminishing 
inflammation, removing acnes, and inhibiting 
melanin regeneration.